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Polyneuropathies and Mononeuropathies Multiplex 

Polyneuropathies and Mononeuropathies Multiplex
Chapter:
Polyneuropathies and Mononeuropathies Multiplex
Author(s):

Jun Kimura

DOI:
10.1093/med/9780199738687.003.0024
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date: 20 September 2021

This chapter reviews the essential characteristics of peripheral neuropathies as they relate to electrophysiologic abnormalities.A commonly used classification of neuropathy employs the anatomic principles of localization and distribution of lesionswith divisions into three major categories. Of these, mononeuropathies comprise any entities with involvement of only one nerve, most commonly at the common sites of compression or entrapment. Polyneuropathies denote a diffuse process affecting all nerves more or less symmetrically, showing length-dependent signs and symptoms. This category comprises those associated with general medical conditions, inflammatory, infective and dysimmune types, metabolic and toxic disorders, and inherited neuropathies. In mononeuropathy multiplex, the disease process affects one nerve at a time but eventually many of them, usually with considerable asymmetry. Electrodiagnostic studies help localize the lesion and distinguish axonal degeneration and demyelination.

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