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Repetitive Nerve Stimulation and Exercise Tests 

Repetitive Nerve Stimulation and Exercise Tests
Chapter:
Repetitive Nerve Stimulation and Exercise Tests
Author(s):

Jun Kimura

DOI:
10.1093/med/9780199738687.003.0018
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date: 22 October 2021

Nerve stimulation techniques as tests for neuromuscular transmission began with Jolly (1895), who applied faradic current repeatedly.The use of supramaximal stimulation and the recording of the muscle action potential have increased the reliability and sensitivity of a train of impulses that causes a progressive change in amplitude of the compound muscle action potential. Later studies have established optimal frequency of stimulation, proper control of temperature, and appropriate selection of muscles.Transmission defects affect a variety of disease states, such as myasthenia gravis, Lambert-Eaton myasthenic syndromes, botulism, amyotrophic lateral sclerosis, poliomyelitis, and multiple sclerosis. This chapter describes decremental or incremental muscle responses elicited by repetitive nerve stimulation,diseasesof neuromuscular transmission disorders, and exercise tests used in the differential diagnosisof myogenic disorders.

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