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Hormones and Mood 

Hormones and Mood
Chapter:
Hormones and Mood
Author(s):

Gail Erlick Robinson

and Sophie Grigoriadis

DOI:
10.1093/med/9780199731855.003.0067
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date: 18 November 2019

Estrogen and progesterone have effects on many parts of the body, including the breast, uterus, heart, bones, and the brain. The effects differ according to the woman’s age, her menopausal status, and whether these hormones are acting together or independently. An imbalance of hormones can alter reproductive function, appearance, and mood as in polycystic ovarian syndrome. Estrogen also has a direct effect on the brain, increasing the growth of neurites and interacting with the neurotransmitters responsible for maintaining mood. Some women appear to be highly sensitive to normal changes in reproductive hormones, making them susceptible to depression and other psychiatric disorders premenstrually and in the perimenopause. The role of estrogen and progesterone in treating these disorders, either directly or as an adjunct to other medications, is still being explored.

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