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Skin substitutes 

Skin substitutes
Chapter:
Skin substitutes
Author(s):

Sujatha Tadiparthi

DOI:
10.1093/med/9780199699537.003.0025
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date: 27 September 2020

Skin substitutes are a heterogeneous group of wound coverage materials that aid in would closure and replace the functions of the skin. They were developed as an adjunct or alternative to autografts. They are available in large quantities, they can provide a mechanical barrier to infection and fluid loss, and enable a neo-dermal base that may help minimize scar contraction. However, they can be expensive, difficult to store with a short half-life and there is a learning curve for their clinical application and use. Skin substitutes can provide either temporary wound cover (eg. Biobrane, TansCyte) or permanent wound cover (eg. Intergra, Matriderm, Alloderm). The features, advantages and disadvantages of the main types of skin substitutes currently in common use are described in this chapter.

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