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Acute kidney injury 

Acute kidney injury
Acute kidney injury

Dharmvir Jaswal

and Adeera Levin

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date: 04 April 2020

Chapter 10 describes ten landmark papers, chosen for their contribution to our understanding of AKI, or because they mark specific time points when concepts or issues were articulated in such a manner as to change practice or shift research paradigms, and range from small meticulous physiology studies to large epidemiological studies. But all serve to inform some key points in the understanding of AKI: mechanisms of ischaemic damage; the importance of tubulo-glomerular feedback as an adaptive mechanism to preserve volume; the pathophysiology of crush syndrome; the insensitivity of serum creatinine as a marker of early damage, and yet the importance of small changes in serum creatinine for prognosis; the importance and danger of fluid resuscitation; and lastly, the notions of iatrogenic kidney damage, acquired as a consequence of radiocontrast administration or other events during hospital admission.

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