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The neurobiology of schizophrenia 

The neurobiology of schizophrenia
Chapter:
The neurobiology of schizophrenia
Author(s):

Paul J. Harrison

DOI:
10.1093/med/9780199696758.003.0077
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date: 27 January 2022

Significant progress has been made in understanding the neurobiology of schizophrenia over the past decade (Table 4.3.6.2.4). In particular, there is now good evidence for a dopaminergic dysfunction, and for structural brain changes that are present at, and in part before, the onset of illness. There is also emerging evidence for several susceptibility genes, accompanied by data suggesting mechanisms by which these genes contribute to the neurodevelopmental and other pathogenic processes that are thought to lead to schizophrenia. Whilst highlighting the progress, one must also acknowledge that much remains unknown (Table 4.3.6.2.5), and it is a moot point how and when the research advances will impact on the diagnosis, treatment, or prognosis of schizophrenia.

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