Show Summary Details
Page of

Neuronal networks, epilepsy, and other brain dysfunctions 

Neuronal networks, epilepsy, and other brain dysfunctions
Neuronal networks, epilepsy, and other brain dysfunctions

John G. R. Jefferys

Page of

PRINTED FROM OXFORD MEDICINE ONLINE ( © Oxford University Press, 2022. All Rights Reserved. Under the terms of the licence agreement, an individual user may print out a PDF of a single chapter of a title in Oxford Medicine Online for personal use (for details see Privacy Policy and Legal Notice).

date: 28 June 2022

The dynamics of highly interconnected networks of neurones are fundamental to both normal and pathological functioning of the brain. Epilepsy is perhaps the most dramatic example of a dysfunctional neuronal network, characterized by intense and highly synchronous neuronal activity, but more subtle dysfunction is associated with other conditions, such as schizophrenia. This chapter will largely focus on the hippocampus, and to a lesser degree on the neocortex. The hippocampal formation is implicated in several important psychiatric and neurological problems. The hippocampus and amygdala are often the site of epileptic foci, which can lead to problems in learning and memory, emotion, anxiety, and other problems. This kind of epilepsy is variously known as temporal lobe epilepsy, complex partial seizures, or limbic epilepsy. The hippocampus and associated limbic areas have been linked both to affective disorders and to psychoses. This chapter will consider the cellular organization of the hippocampus and then outline aspects of the emergent properties of neuronal networks in the hippocampus and speculative role in psychiatric disorders. Cellular and network mechanisms of focal epilepsy, and learning impairments associated with limbic epilepsy will be reviewed.

Access to the complete content on Oxford Medicine Online requires a subscription or purchase. Public users are able to search the site and view the abstracts for each book and chapter without a subscription.

Please subscribe or login to access full text content.

If you have purchased a print title that contains an access token, please see the token for information about how to register your code.

For questions on access or troubleshooting, please check our FAQs, and if you can't find the answer there, please contact us.