- Section 1 The Subject Matter of and Approach to Psychiatry
- 1.3 Psychiatry as a worldwide public health problem
- 1.4 The history of psychiatry as a medical specialty
- 1.5 Ethics and values
- 1.6 The psychiatrist as a manager
- 1.7 Descriptive phenomenology
- 1.8 Assessment
- 1.9 Diagnosis and classification
- 1.10 From science to practice
- Section 2 The Scientific Basis of Psychiatric Aetiology
- 2.3 The contribution of neurosciences
- 2.4 The contribution of genetics
- 2.5 The contribution of psychological science
- 2.6 The contribution of social sciences
- 2.7 The contribution of epidemiology to psychiatric aetiology
- Section 3 Psychodynamic Contributions to Psychiatry
- Section 4 Clinical Syndromes of Adult Psychiatry
- 4.4 Persistent delusional symptoms and disorders
- 4.5 Mood disorders
- 4.6 Stress-related and adjustment disorders
- 4.7 Anxiety disorders
- 4.7.1 Generalized anxiety disorders
- 4.7.2 Social anxiety disorder and specific phobias
- 4.7.3 Panic disorder and agoraphobia
- 4.8 Obsessive–compulsive disorder
- 4.9 Depersonalization disorder
- 4.10 Disorders of eating
- 4.11 Sexuality, gender identity, and their disorders
- 4.12 Personality disorders
- 4.13 Habit and impulse control disorder
- 4.14 Sleep–wake disorders
- 4.15 Suicide
- 4.16 Culture-related specific psychiatric syndromes
- Section 5 Psychiatry and Medicine
- Section 6 Treatment Methods in Psychiatry
- 6.2 Somatic treatments
- Section 7 Social Psychiatry and Service Provision
- Section 8 The Psychiatry of Old Age
- Section 9 Child and Adolescent Psychiatry
(p. 765) Obsessive–compulsive disorder
- Chapter:
- (p. 765) Obsessive–compulsive disorder
- Author(s):
Joseph Zohar
, Leah Fostick
, and Elizabeth Juven-Wetzler
- DOI:
- 10.1093/med/9780199696758.003.0100
The efficacy of the SRIs for OCD, together with the lack of efficacy of adrenergic antidepressants, has suggested that serotonin is involved in the pathophysiology of OCD. This relationship was validated by research on serotonergic markers in OCD and by the challenge paradigm. Which type of serotonergic receptor is involved in the pathogenesis and/or the mechanism of action of anti-obsessional drugs, is still unclear. However, the possible role of 5HT1B has emerged. Further studies are crucial for elucidating the role of serotonin and other neurotransmitters (i.e. dopamine) in the pathophysiology and management of OCD.
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- Section 1 The Subject Matter of and Approach to Psychiatry
- 1.3 Psychiatry as a worldwide public health problem
- 1.4 The history of psychiatry as a medical specialty
- 1.5 Ethics and values
- 1.6 The psychiatrist as a manager
- 1.7 Descriptive phenomenology
- 1.8 Assessment
- 1.9 Diagnosis and classification
- 1.10 From science to practice
- Section 2 The Scientific Basis of Psychiatric Aetiology
- 2.3 The contribution of neurosciences
- 2.4 The contribution of genetics
- 2.5 The contribution of psychological science
- 2.6 The contribution of social sciences
- 2.7 The contribution of epidemiology to psychiatric aetiology
- Section 3 Psychodynamic Contributions to Psychiatry
- Section 4 Clinical Syndromes of Adult Psychiatry
- 4.4 Persistent delusional symptoms and disorders
- 4.5 Mood disorders
- 4.6 Stress-related and adjustment disorders
- 4.7 Anxiety disorders
- 4.7.1 Generalized anxiety disorders
- 4.7.2 Social anxiety disorder and specific phobias
- 4.7.3 Panic disorder and agoraphobia
- 4.8 Obsessive–compulsive disorder
- 4.9 Depersonalization disorder
- 4.10 Disorders of eating
- 4.11 Sexuality, gender identity, and their disorders
- 4.12 Personality disorders
- 4.13 Habit and impulse control disorder
- 4.14 Sleep–wake disorders
- 4.15 Suicide
- 4.16 Culture-related specific psychiatric syndromes
- Section 5 Psychiatry and Medicine
- Section 6 Treatment Methods in Psychiatry
- 6.2 Somatic treatments
- Section 7 Social Psychiatry and Service Provision
- Section 8 The Psychiatry of Old Age
- Section 9 Child and Adolescent Psychiatry