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Antiepileptic drugs 

Antiepileptic drugs
Chapter:
Antiepileptic drugs
Author(s):

Brian P. Brennan

and Harrison G. Pope Jr.

DOI:
10.1093/med/9780199696758.003.0156
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date: 23 June 2021

Several drugs originally developed to treat epilepsy have been found effective in certain psychiatric disorders. This chapter reviews the antiepileptic drugs most extensively studied in psychiatric disorders: valproate, carbamazepine, lamotrigine, and topiramate. We then briefly mention six other antiepileptics currently under investigation in various psychiatric disorders, but not yet extensively studied: gabapentin, oxcarbazepine, levetiracetam, tiagabine, zonisamide, and pregabalin. The antiepileptic drug phenytoin is rarely used in psychiatric disorders, and is therefore not included in this chapter. The benzodiazepines, which have antiepileptic properties, are also omitted here, as they are discussed in Chapter 6.2.2. We briefly list studies documenting the efficacy of these various agents in psychiatric disorders, but the reader is referred to the individual chapters on specific disorders for a more detailed discussion of treatment strategies.

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