- Section 1 The Subject Matter of and Approach to Psychiatry
- 1.3 Psychiatry as a worldwide public health problem
- 1.4 The history of psychiatry as a medical specialty
- 1.5 Ethics and values
- 1.6 The psychiatrist as a manager
- 1.7 Descriptive phenomenology
- 1.8 Assessment
- 1.9 Diagnosis and classification
- 1.10 From science to practice
- Section 2 The Scientific Basis of Psychiatric Aetiology
- 2.3 The contribution of neurosciences
- 2.4 The contribution of genetics
- 2.5 The contribution of psychological science
- 2.6 The contribution of social sciences
- 2.7 The contribution of epidemiology to psychiatric aetiology
- Section 3 Psychodynamic Contributions to Psychiatry
- Section 4 Clinical Syndromes of Adult Psychiatry
- 4.4 Persistent delusional symptoms and disorders
- 4.5 Mood disorders
- 4.6 Stress-related and adjustment disorders
- 4.7 Anxiety disorders
- Section 5 Psychiatry and Medicine
- Section 6 Treatment Methods in Psychiatry
- 6.2 Somatic treatments
- 6.2.1 General principles of drug therapy in psychiatry
- 6.2.2 Anxiolytics and hypnotics
- 6.2.3 Antidepressants
- 6.2.4 Lithium and related mood stabilizers
- 6.2.5 Antipsychotic and anticholinergic drugs
- 6.2.6 Antiepileptic drugs
- 6.2.7 Drugs for cognitive disorders
- 6.2.8 Drugs used in the treatment of the addictions
- 6.2.9 Complementary medicines
- 6.2.10 Non-pharmacological somatic treatments
- 6.3 Psychological treatments
- 6.4 Treatment by other professions
- 6.5 Indigenous, folk healing practices
- Section 7 Social Psychiatry and Service Provision
- Section 8 The Psychiatry of Old Age
- Section 9 Child and Adolescent Psychiatry
(p. 1185) Antidepressants
- Chapter:
- (p. 1185) Antidepressants
- Author(s):
Zubin Bhagwagar
and George R. Heninger
- DOI:
- 10.1093/med/9780199696758.003.0153
Major depressive disorder is a serious, recurrent illness which levies a crippling toll on individuals, families, and society in general. The importance of depression as a major public health problem is emphasized by findings from the World Health Organization Global Burden of Disease survey in showing that in 1990 it was the fourth largest cause of burden of disease (i.e. years of life lost due either to premature mortality or to years lived with a disability). It has been estimated that by the year 2020 it is expected to be the second largest cause of burden of disease. Depression is underdiagnosed and frequently under-treated, and depressed individuals have a much higher risk for suicide. The primary treatment for depression involves the use of antidepressant drugs, and it is therefore important that clinicians become familiar with and adept in utilizing this important group of compounds. Although primarily used for the treatment of depression, drugs within this category also have a number of other important uses. A thorough understanding of the pharmacology of antidepressants will aid the clinician in the selective use of these drugs for patients with depression as well as patients with a number of other disorders.
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- Section 1 The Subject Matter of and Approach to Psychiatry
- 1.3 Psychiatry as a worldwide public health problem
- 1.4 The history of psychiatry as a medical specialty
- 1.5 Ethics and values
- 1.6 The psychiatrist as a manager
- 1.7 Descriptive phenomenology
- 1.8 Assessment
- 1.9 Diagnosis and classification
- 1.10 From science to practice
- Section 2 The Scientific Basis of Psychiatric Aetiology
- 2.3 The contribution of neurosciences
- 2.4 The contribution of genetics
- 2.5 The contribution of psychological science
- 2.6 The contribution of social sciences
- 2.7 The contribution of epidemiology to psychiatric aetiology
- Section 3 Psychodynamic Contributions to Psychiatry
- Section 4 Clinical Syndromes of Adult Psychiatry
- 4.4 Persistent delusional symptoms and disorders
- 4.5 Mood disorders
- 4.6 Stress-related and adjustment disorders
- 4.7 Anxiety disorders
- Section 5 Psychiatry and Medicine
- Section 6 Treatment Methods in Psychiatry
- 6.2 Somatic treatments
- 6.2.1 General principles of drug therapy in psychiatry
- 6.2.2 Anxiolytics and hypnotics
- 6.2.3 Antidepressants
- 6.2.4 Lithium and related mood stabilizers
- 6.2.5 Antipsychotic and anticholinergic drugs
- 6.2.6 Antiepileptic drugs
- 6.2.7 Drugs for cognitive disorders
- 6.2.8 Drugs used in the treatment of the addictions
- 6.2.9 Complementary medicines
- 6.2.10 Non-pharmacological somatic treatments
- 6.3 Psychological treatments
- 6.4 Treatment by other professions
- 6.5 Indigenous, folk healing practices
- Section 7 Social Psychiatry and Service Provision
- Section 8 The Psychiatry of Old Age
- Section 9 Child and Adolescent Psychiatry