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Clinical and laboratory features of musculoskeletal manifestations 

Clinical and laboratory features of musculoskeletal manifestations
Clinical and laboratory features of musculoskeletal manifestations

Dafna D. Gladman

, Cheryl F. Rosen

, and Vinod Chandran

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date: 30 May 2020

Musculoskeletal disease in psoriatic arthritis is described in four domains: peripheral arthritis, axial arthritis, enthesitis and dactylitis

Peripheral arthritis in psoriatic arthritis may range from mono to oligoarthritis and can affect any joint including the distal interphalangeal joints.

Axial arthritis, although common, is usually less severe and may often be distinguished from ankylosing spondylitis by the presence of asymmetric sacroiliitis, paramarginal syndesmophytes and less frequent involvement of the lumbar spine.

Dactylitis, defined as swelling of an entire digit, occurs in 30-50% of patients with psoriatic arthritis, and is a marker of disease severity

Acute phase reactants are often normal in patients with active disease; however, elevation of acute phase reactants is a prognostic marker

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