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Aetiology and pathogenesis 

Aetiology and pathogenesis
Aetiology and pathogenesis

Dafna D. Gladman

, Cheryl F. Rosen

, and Vinod Chandran

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date: 29 May 2020

Psoriatic arthritis has a significant familial component with a sibling recurrence risk ratio of 30

Several susceptibility genes for psoriasis and psoriatic arthritis have been identified, with the most important genes being within the MHC region on chromosome 6p

Environmental factors such as trauma, infection and smoking influence susceptibility to psoriatic arthritis

Enthesitis may be the unifying pathologic lesion to explain the varied clinical manifestations of PsA

Pathogenesis involves tissue specific factors, including microtrauma, leading to regional innate immune activation and persistent inflammation

Persistent inflammation leads to joint damage with varying degrees of either bony erosion and osteolysis or new bone formation and ankylosis

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