Show Summary Details
Page of

Aetiology and pathogenesis 

Aetiology and pathogenesis
Chapter:
Aetiology and pathogenesis
Author(s):

Dafna D. Gladman

, Cheryl F. Rosen

, and Vinod Chandran

DOI:
10.1093/med/9780199692095.003.0003
Page of

PRINTED FROM OXFORD MEDICINE ONLINE (www.oxfordmedicine.com). © Oxford University Press, 2020. All Rights Reserved. Under the terms of the licence agreement, an individual user may print out a PDF of a single chapter of a title in Oxford Medicine Online for personal use (for details see Privacy Policy and Legal Notice).

date: 29 May 2020

Psoriatic arthritis has a significant familial component with a sibling recurrence risk ratio of 30

Several susceptibility genes for psoriasis and psoriatic arthritis have been identified, with the most important genes being within the MHC region on chromosome 6p

Environmental factors such as trauma, infection and smoking influence susceptibility to psoriatic arthritis

Enthesitis may be the unifying pathologic lesion to explain the varied clinical manifestations of PsA

Pathogenesis involves tissue specific factors, including microtrauma, leading to regional innate immune activation and persistent inflammation

Persistent inflammation leads to joint damage with varying degrees of either bony erosion and osteolysis or new bone formation and ankylosis

Access to the complete content on Oxford Medicine Online requires a subscription or purchase. Public users are able to search the site and view the abstracts for each book and chapter without a subscription.

Please subscribe or login to access full text content.

If you have purchased a print title that contains an access token, please see the token for information about how to register your code.

For questions on access or troubleshooting, please check our FAQs, and if you can't find the answer there, please contact us.