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Synthetic antibacterial agents and miscellaneous antibiotics 

Synthetic antibacterial agents and miscellaneous antibiotics
Chapter:
Synthetic antibacterial agents and miscellaneous antibiotics
Author(s):

Peter Davey

, Mark Wilcox

, William Irving

, and Guy Thwaites

DOI:
10.1093/med/9780199689774.003.0004
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date: 27 July 2021

Various targets other than the cell wall and ribosome are open to attack by chemotherapeutic agents. This chapter describes the properties of inhibitors of bacterial nucleic acid synthesis, compounds that act on the bacterial cell membrane, and agents used solely for the treatment of mycobacterial disease. Many of these compounds are synthetic antibacterial drugs rather than antibiotics in the strict sense. This chapter describes the properties of inhibitors of bacterial nucleic acid synthesis compounds (including sulphonamides, diaminopyrimidines (e.g. trimethoprim), quinolones, nitroimidazoles (e.g. metronidazole), nitrofurans (e.g. nitrofurantoin), and the rifamycins (e.g. rifampicin)), agents that act on the bacterial cell membrane (including polymyxins and other membrane-active agents), and agents used solely for the treatment of mycobacterial disease.

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