- Preface
- Abbreviations
- Contributors
- Chapter 1 Nerve, muscle, and neuromuscular junction
- Chapter 2 The motor unit
- Chapter 3 Motor control: spinal and cortical mechanisms
- Chapter 4 Cortical activity: single cell, cell assemblages, and networks
- Chapter 5 Recording of neural signals, neural activation, and signal processing
- Chapter 6 Nerve conduction studies
- Chapter 7 Electromyography
- Chapter 8 Quantitative electromyography
- Chapter 9 Axonal excitability: molecular basis and assessment in the clinic
- Chapter 10 Reflex studies
- Chapter 11 Electroencephalography
- Chapter 12 Intracranial electroencephalographic recordings
- Chapter 13 Magnetoencephalography
- Chapter 14 Transcranial magnetic stimulation
- Chapter 15 Evoked potentials
- Chapter 16 Polysomnography and other investigations for sleep disorders
- Chapter 17 Clinical neurophysiology of the pelvic floor
- Chapter 18 The clinical approach to neurophysiology
- Chapter 19 Focal neuropathies
- Chapter 20 Generalized peripheral neuropathies
- Chapter 21 Disorders of single nerves, roots, and plexuses
- Chapter 22 Neurophysiology in amyotrophic lateral sclerosis and other motor degenerations
- Chapter 23 Clinical aspects of neuromuscular junction disorders
- Chapter 24 Primary muscle diseases
- Chapter 25 Paediatric conditions
- Chapter 26 EMG-guided botulinum toxin therapy
- Chapter 27 Genetic generalized epilepsy
- Chapter 28 Focal epilepsy
- Chapter 29 Syncope
- Chapter 30 Convulsive and non-convulsive status epilepticus
- Chapter 31 Presurgical evaluation for epilepsy surgery
- Chapter 32 Encephalopathy, central nervous system infections, and coma
- Chapter 33 Migraine, stroke, and cerebral ischaemia
- Chapter 34 Electroclinical features of paediatric conditions
- Chapter 35 Sleep disorders
- Chapter 36 Intraoperative monitoring
- Index
(p. 97) Axonal excitability: molecular basis and assessment in the clinic
- Chapter:
- (p. 97) Axonal excitability: molecular basis and assessment in the clinic
- Author(s):
Susanna B. Park
, Cindy S-Y. Lin
, and Matthew C. Kiernan
- DOI:
- 10.1093/med/9780199688395.003.0009
Axonal excitability techniques were developed to assess axonal resting membrane potential and ion channel function in vivo, and thereby provide greater molecular understanding of the activity of voltage gated ion channels and ion pumps underlying nerve and membrane function. Axonal excitability studies provide complimentary information to conventional nerve conduction studies, using submaximal stimuli to examine the properties underlying the excitability of the axon. Such techniques have been developed both as a research technique to examine disease pathophysiology and as a clinical investigation technique. This chapter provides an overview of axonal excitability techniques, addressing the role of key ion channels and pumps in membrane function and highlighting examples of clinical case studies, where such techniques have been utilized, including motor neuronopathies, tracking progression of chemotherapy-induced peripheral neuropathy, and assessing treatment response in chronic inflammatory demyelinating polyneuropathy.
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- Preface
- Abbreviations
- Contributors
- Chapter 1 Nerve, muscle, and neuromuscular junction
- Chapter 2 The motor unit
- Chapter 3 Motor control: spinal and cortical mechanisms
- Chapter 4 Cortical activity: single cell, cell assemblages, and networks
- Chapter 5 Recording of neural signals, neural activation, and signal processing
- Chapter 6 Nerve conduction studies
- Chapter 7 Electromyography
- Chapter 8 Quantitative electromyography
- Chapter 9 Axonal excitability: molecular basis and assessment in the clinic
- Chapter 10 Reflex studies
- Chapter 11 Electroencephalography
- Chapter 12 Intracranial electroencephalographic recordings
- Chapter 13 Magnetoencephalography
- Chapter 14 Transcranial magnetic stimulation
- Chapter 15 Evoked potentials
- Chapter 16 Polysomnography and other investigations for sleep disorders
- Chapter 17 Clinical neurophysiology of the pelvic floor
- Chapter 18 The clinical approach to neurophysiology
- Chapter 19 Focal neuropathies
- Chapter 20 Generalized peripheral neuropathies
- Chapter 21 Disorders of single nerves, roots, and plexuses
- Chapter 22 Neurophysiology in amyotrophic lateral sclerosis and other motor degenerations
- Chapter 23 Clinical aspects of neuromuscular junction disorders
- Chapter 24 Primary muscle diseases
- Chapter 25 Paediatric conditions
- Chapter 26 EMG-guided botulinum toxin therapy
- Chapter 27 Genetic generalized epilepsy
- Chapter 28 Focal epilepsy
- Chapter 29 Syncope
- Chapter 30 Convulsive and non-convulsive status epilepticus
- Chapter 31 Presurgical evaluation for epilepsy surgery
- Chapter 32 Encephalopathy, central nervous system infections, and coma
- Chapter 33 Migraine, stroke, and cerebral ischaemia
- Chapter 34 Electroclinical features of paediatric conditions
- Chapter 35 Sleep disorders
- Chapter 36 Intraoperative monitoring
- Index