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Generalized peripheral neuropathies 

Generalized peripheral neuropathies
Chapter:
Generalized peripheral neuropathies
Author(s):

Hessel Franssen

DOI:
10.1093/med/9780199688395.003.0020
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date: 29 March 2020

The chapter on generalized peripheral neuropathies describes how to perform and interpret electrophysiological studies aimed at diagnosing polyneuropathy. It first reviews methodological issues, such as stimulation and recording, and takes into account temperature. Next, the relevant pathophysiology of single myelinated axons, as found in animal experiments, is discussed and related to findings on nerve conduction studies performed in patients. This is followed by a discussion of criteria for axon loss and demyelination. Finally, typical findings in specific neuropathies are described and examples of typical findings are shown in the figures.

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