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Paul L. Furlong

, Elaine Foley

, Caroline Witton

, and Stefano Seri

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date: 17 May 2022

For presurgical assessments for resection of an epileptogenic lesion or zone, evaluations over the last 20 years have established magnetoencephalography (MEG) as a valuable tool in routine clinical practice in both adult and paediatric age groups. MEG can accurately localize both ictal and inter-ictal spike sources. MEG yields important additional information in around 30% of patients with epilepsy of suspected neocortical origin, aiding in the modification or extension of invasive measurements. Seizure freedom is most likely to occur when there is concordance between electroencephalogram (EEG) and MEG localization, and least likely to occur when these results are divergent. In some patients, invasive recordings may not be viable or repeatable. In these cases, MEG localization frequently provides additional information for planning surgery. Recent developments in technology for movement compensation and enhanced noise reduction provide optimism for continually improving outcomes of MEG-enhanced presurgical evaluations.

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