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Metabolic Bone Disease 

Metabolic Bone Disease
Chapter:
Metabolic Bone Disease
Author(s):

Ashok Bhalla

and Tehseen Ahmed

DOI:
10.1093/med/9780199688371.003.0009
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date: 22 July 2019

The term ‘metabolic bone disease’ covers a wide variety of disorders that can ultimately lead to alteration in bone strength. The disorders can be both inherited and acquired. Abnormalities of calcium, phosphate, and/or vitamin D are commonly seen. However, the most common metabolic bone disorder is osteoporosis, in which the density and quality of bone architecture is adversely affected. Osteoporosis is a major health problem, with one in two women and one in five men over the age of 50 expected to sustain a fragility fracture in their remaining lifetime. As one might expect, this leads to significant morbidity and excess mortality. Osteoporosis can be expected to represent an increasing burden on health resources as life expectancy continues to increase. In this chapter, eight landmark papers have been chosen that cover various aspects of metabolic bone disease, but with a primary focus on osteoporosis.

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