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Systemic Lupus Erythematosus 

Systemic Lupus Erythematosus
Chapter:
Systemic Lupus Erythematosus
Author(s):

Benjamin Parker

and Ian N. Bruce

DOI:
10.1093/med/9780199688371.003.0004
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date: 25 January 2020

Major advances in the understanding of systemic lupus erythematosus (SLE) and related disorders have taken place over the past 50 years. Understanding has increased as researchers have gained insights into the key pathological processes that underlie these conditions. It is now clear that SLE fits within the family of systemic autoimmune rheumatic diseases; however, this started as a hypothesis as recently as the 1940s. The inflammatory and autoimmune nature of the condition has also taken time to be confirmed. In this chapter, several landmark papers have been chosen that describe key discoveries that lead to a better understanding of SLE pathogenesis and how this understanding translates to better diagnostic tests and systems to classify patients with SLE.

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