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Gender considerations in acute coronary syndromes 

Gender considerations in acute coronary syndromes
Chapter:
Gender considerations in acute coronary syndromes
Author(s):

Eva Swahn

, Joakim Alfredsson

, and Sofia Sederholm Lawesson

DOI:
10.1093/med/9780199687039.003.0050_update_002

Update:

Major update, revised pre-existing segments and added new ones with many new studies. “Non-obstructive disease,” “The Takotsubo syndrome,” “Young women with MI including spontaneous coronary artery dissection,” “Risk factors”, and “Sex differences in benefit from invasive treatment in non-ST-segment elevation acute coronary syndromes”

Over 40 new references

3 new Tables

Updated on 22 February 2018. The previous version of this content can be found here.
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date: 21 October 2019

It is a very important issue to enlighten on gender differences and similarities regarding the management of patients with acute coronary syndromes. It is a fact that women have not been included in clinical trials in numbers equal to men, for whatever reason. In the future, it will be necessary to individualize, as much as possible, the management of patients, regardless of gender. To get there, it is necessary to have sufficient numbers of patients from both genders included in trials, or otherwise it is not possible to draw proper conclusions. Until now, most results regarding women and acute coronary syndromes have been based on substudy analyses with inadequate statistical power. If gender differences have become evident in studies with gender-mixed populations, it seems obvious that the calculated power to show significant differences is also inadequate for men. There is an urgent need of more research in this area, in order not to harm our patients with our treatment because of a paucity of knowledge. It is also as important not to withdraw proper treatment from certain individuals when they can benefit from it.

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