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The glutamate system and addiction 

The glutamate system and addiction
The glutamate system and addiction

Professor David J. Nutt

and Dr Liam J. Nestor

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date: 21 June 2021

Addiction involves enduring neuroplasticity in the reward circuitry of the brain

Neuroplasticity is a result of glutamate-dependent long-term potentiation

Glutamate is an excitatory neurotransmitter

Glutamate release is involved in alcohol and drug relapse in response to drug cues

There are changes in glutamate receptor functioning in substance addiction

Medications that reduce glutamate tone may prevent alcohol and drug relapse

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