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The GABA system and addiction 

The GABA system and addiction
The GABA system and addiction

Professor David J. Nutt

and Dr Liam J. Nestor

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date: 28 July 2021

GABA is the major inhibitory neurotransmitter in the brain

GABA binds with GABAA and GABAB receptors to inhibit neuronal activity

Substances of abuse can down regulate or up regulate the GABA system

GABAB receptors modulate substance reward and reinforcement behaviours

Disturbances to the GABA system may predate substance addiction

Compounds that target the GABA system may help in the treatment of addiction

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