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The dopamine system and addiction 

The dopamine system and addiction
The dopamine system and addiction

Professor David J. Nutt

and Dr Liam J. Nestor

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date: 21 June 2021

Dopamine release is involved in the reinforcing effects of addictive substances

Dopamine release can be blunted by substance abuse

Dopamine release is involved in drug craving

Dopamine receptors are reduced during substance addiction withdrawal

Medications that boost dopamine functioning may be useful in substance addiction

Reductions in dopamine functioning may predispose people to substance addiction

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