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Drug pharmacokinetics and abuse liability 

Drug pharmacokinetics and abuse liability
Chapter:
Drug pharmacokinetics and abuse liability
Author(s):

Professor David J. Nutt

and Dr Liam J. Nestor

DOI:
10.1093/med/9780199685707.003.0005
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date: 21 February 2020

Pharmacokinetics refers to the effect of the body on drugs

Pharmacokinetics predict the abuse liability of drugs

Route of administration (e.g., iv) predicts the speed at which drugs peak in plasma

Drugs that are quickly released have a greater abuse liability

The half-life of a drug can predict its reinforcing effects

Metabolism by the liver can predict a drug’s reinforcing effects during withdrawal

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