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Neurobiological processes in addiction 

Neurobiological processes in addiction
Neurobiological processes in addiction

Professor David J. Nutt

and Dr Liam J. Nestor

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date: 21 June 2021

The brain controls necessary motivational and cognitive processes

These processes involve a network of independent and overlapping brain circuits

These processes involve reward, motivation, learning/memory and cognition

Reward involve dopamine in the ventral striatum

Learning involves dopamine in the ventral tegmental area and ventral striatum

Memory involves glutamate in the amygdala and hippocampus

Motivation and drive involve GABA and dopamine in the orbitofrontal cortex

Cognition involves dopamine and glutamate in the prefrontal cortex

These processes are disrupted by substances of addiction

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