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Transferability of the results from trials 

Transferability of the results from trials
Chapter:
Transferability of the results from trials
Author(s):

Dr. Henry A. Glick

, Dr. Jalpa A. Doshi

, Dr. Seema S. Sonnad

, and Dr. Daniel Polsky

DOI:
10.1093/med/9780199685028.003.0010
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date: 25 August 2019

This chapter discusses the transferability or generalizability of trial results, a second form of uncertainty that differs from sampling uncertainty. It identifies the problem: potential heterogeneity in countries’ epidemiology, practice patterns, and absolute and relative price weights (unit costs). It also discusses the evidence related to whether differences in the use of medical services or differences in price weights pose greater problems for transferability, concluding that current evidence suggests that differences in use of medical services are more of a greater problem than are differences in price weights. Finally, it describes three analytic approaches for assessing transferability. These include fixed effects models, tests of homogeneity, and multilevel models with rand effects empirical Bayesian shrinkage estimators.

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