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Biologically based exposure assessment for epidemiology 

Biologically based exposure assessment for epidemiology
Chapter:
Biologically based exposure assessment for epidemiology
Author(s):

Thomas J. Smith

and David Kriebel

DOI:
10.1093/med/9780199683901.003.0016
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date: 21 October 2020

The ‘right’ choice of summary measure of exposure in epidemiological studies has long been a dilemma for study design and data analysis in environmental and occupational epidemiology. This chapter propose a new approach that offers a clear rationale and method for choosing a biologically appropriate exposure metric based on two simple, directly observable dimensions: (1) is the pathological effect reversible or irreversible across time? (2) Is the magnitude of the effect proportional to the exposure, or is it a discrete response triggered when a critical level of exposure is reached?

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