Show Summary Details
Page of

Occupational risk factors in lung cancer: pooling community-based case-control studies for enhanced evidence 

Occupational risk factors in lung cancer: pooling community-based case-control studies for enhanced evidence
Chapter:
Occupational risk factors in lung cancer: pooling community-based case-control studies for enhanced evidence
Author(s):

Hans Kromhout

, Ann Olsson

, Susan Peters

, and Kurt Straif

DOI:
10.1093/med/9780199683901.003.0013
Page of

PRINTED FROM OXFORD MEDICINE ONLINE (www.oxfordmedicine.com). © Oxford University Press, 2020. All Rights Reserved. Under the terms of the licence agreement, an individual user may print out a PDF of a single chapter of a title in Oxford Medicine Online for personal use (for details see Privacy Policy and Legal Notice).

date: 02 April 2020

Exposure to the majority of known and suspected lung carcinogens originates from occupational settings and affects millions of workers worldwide. A considerable amount of evidence and knowledge has been collected via epidemiological studies but several important questions remain unanswered. For instance, little is known about risks among non-smokers and exposed female workers. Also, despite speculation about interactions between smoking and multiple or serial exposures to lung carcinogens, there is only limited evidence on effect modification. Pooling case–control studies can provide the statistical power needed to address these outstanding issues. The SYNERGYproject which pools community-based lung cancer case–control studies was set up for this purpose and additionally tried to estimate exposure to five major lung carcinogens quantitatively by mining existing exposure measurement databases. This chapter describes the challenges and possibilities of pooling community-based studies and making their exposure assessments comparable with those from industry-based studies.

Access to the complete content on Oxford Medicine Online requires a subscription or purchase. Public users are able to search the site and view the abstracts for each book and chapter without a subscription.

Please subscribe or login to access full text content.

If you have purchased a print title that contains an access token, please see the token for information about how to register your code.

For questions on access or troubleshooting, please check our FAQs, and if you can't find the answer there, please contact us.