Show Summary Details
Page of

Gastrointestinal functioning during sleep 

Gastrointestinal functioning during sleep
Chapter:
Gastrointestinal functioning during sleep
Author(s):

William C. Orr

DOI:
10.1093/med/9780199682003.003.0042
Page of

PRINTED FROM OXFORD MEDICINE ONLINE (www.oxfordmedicine.com). © Oxford University Press, 2020. All Rights Reserved. Under the terms of the licence agreement, an individual user may print out a PDF of a single chapter of a title in Oxford Medicine Online for personal use (for details see Privacy Policy and Legal Notice).

date: 19 October 2020

Sleep is associated with substantial changes in gastrointestinal functioning that have considerable clinical relevance Symptoms of sleep-related dysfunction are common and are primarily related to sleep-related heartburn and regurgitation. Sleep disturbances accompany several other gastrointestinal disorders, such as irritable bowel syndrome (IBS). Sleep-related gastroesophageal reflux (GER) has been shown to plan a major role in the pathogenesis of more complicated gastroesophageal reflux disease (GERD), notably via a prolongation of acid contact. Mucosal damage has been shown to be more closely associated with this pattern of reflux in comparison with waking reflux, which is associated with more frequent but very short reflux events. Sleep disturbance is also associated with a visceral hyperalgesia that enhances pain responses associated with acid–mucosal contact. Sleep does influence intestinal motility, but further research is needed to confirm the details of exactly how intestinal motility is modulated by sleep.

Access to the complete content on Oxford Medicine Online requires a subscription or purchase. Public users are able to search the site and view the abstracts for each book and chapter without a subscription.

Please subscribe or login to access full text content.

If you have purchased a print title that contains an access token, please see the token for information about how to register your code.

For questions on access or troubleshooting, please check our FAQs, and if you can't find the answer there, please contact us.