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Neuromuscular disorders and sleep 

Neuromuscular disorders and sleep
Neuromuscular disorders and sleep

Katerina Sajgalikova

, Erik K. St. Louis

, and Peter Gay

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date: 19 October 2020

This chapter examines the range of sleep disturbances seen in patients with neuromuscular disorders, particularly emphasizing sleep-related breathing disorders which may be a presenting manifestation of neuromuscular disorders, and which significantly contribute to morbidity and mortality in this patient population. It provides an overview of physiological and pathological alterations in neuromuscular breathing mechanisms and control during sleep. The symptoms and forms of sleep disordered breathing (SDB) seen in specific neuromuscular disorders such as amyotrophic lateral sclerosis, myopathies, and disorders of neuromuscular junction transmission are reviewed. The chapter concludes with a discussion of management strategies for neuromuscular disorder patients with SDB, which is common in such patients, requiring generalists, neurologists, and sleep physicians to work together toward prompt diagnosis and optimal treatment approaches.

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