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Sleep disorders in neurodegenerative diseases other than Parkinson disease and multiple system atrophy 

Sleep disorders in neurodegenerative diseases other than Parkinson disease and multiple system atrophy
Chapter:
Sleep disorders in neurodegenerative diseases other than Parkinson disease and multiple system atrophy
Author(s):

Raffaele Manni

, and Michele Terzaghi

DOI:
10.1093/med/9780199682003.003.0026
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date: 19 February 2020

This chapter examines sleep–wake disturbances occurring in the most common neurodegenerative disorders. It reviews sleep alterations in Alzheimer disease and dementia with Lewy bodies. It also discusses sleep problems in progressive supranuclear palsy, corticobasal degeneration, Huntington disease, and spinocerebellar ataxias. Status dissociatus as an extreme form of sleep alteration in advanced neurodegenerative diseases is also considered. The chapter reviews the key points for the treatment of disrupted sleep in neurodegenerative disorders, with a focus on pharmacological and nonpharmacological interventions to improve sleep continuity. It also summarizes paraphysiological age-related changes in sleep patterns and discusses indications and procedures for clinical and instrumental assessment of sleep disorders in neurodegenerative disorders.

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