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Contraindications, cautions, and drug interactions 

Contraindications, cautions, and drug interactions
Contraindications, cautions, and drug interactions

Cathy Stannard

, Michael Coupe

, and Anthony Pickering

Page of

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date: 28 November 2021

There are few absolute contraindications to opioid use. Renal and hepatic disease can result in significant alterations in drug handling, and dose reductions may be required. Opioids have a number of important drug interactions, which can result in altered pharmacokinetics or pharmacodynamics.

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