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Opioid-induced hyperalgesia 

Opioid-induced hyperalgesia
Chapter:
Opioid-induced hyperalgesia
Author(s):

Cathy Stannard

, Michael Coupe

, and Anthony Pickering

DOI:
10.1093/med/9780199678075.003.0008
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date: 25 August 2019

Opioids have been shown in animal models to induce hyperalgesic states, particularly on withdrawal. This phenomenon has also been seen in human experimental models, and it appears to occur in clinical practice. The clinical importance of opioid-induced hyperalgesia in chronic pain remains to be fully evaluated.

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