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Opioid actions: insights from imaging 

Opioid actions: insights from imaging
Chapter:
Opioid actions: insights from imaging
Author(s):

Cathy Stannard

, Michael Coupe

, and Anthony Pickering

DOI:
10.1093/med/9780199678075.003.0003
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date: 20 October 2019

The use of radiolabelled opioid ligands has enabled the distribution of receptors to be mapped in health and in some chronic pain conditions. Changes in the receptor distribution have been suggested to play a role in the pathology of some chronic pain states and may also be associated with heritable traits such as COMT polymorphism. Dynamic assessment of radioligand binding has been used to reveal the engagement of the endogenous opioid system during maintained painful stimulation and during placebo expectation of analgesia. Activation of areas, such as the anterior cingulate cortex, appears to be associated with the analgesic effects of exogenous opioids.

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