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Opioid pharmacology 

Opioid pharmacology
Opioid pharmacology

Cathy Stannard

, Michael Coupe

, and Anthony Pickering

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date: 11 July 2020

Opioids act through μ‎, κ‎, and δ‎ G-protein coupled receptors. The opioid peptides and receptors form an endogenous analgesic system. Opioid analgesics exert their therapeutic action through μ‎-receptors. Most of the opioid adverse effects are due to μ‎-receptor activation. The rational choice of opioids is governed by their pharmacokinetic profiles and patient’s individual responses to agents. Morphine remains a good starting point to assess the opioid sensitivity of a pain condition.

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