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Viral platforms for expression of tumor antigens in cancer immunotherapy 

Viral platforms for expression of tumor antigens in cancer immunotherapy
Chapter:
Viral platforms for expression of tumor antigens in cancer immunotherapy
Author(s):

Karishma Rajani

, Vanessa Alonso-Camino

, Nicolas Boisgerault

, and Richard Vile

DOI:
10.1093/med/9780199676866.003.0015
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date: 10 December 2019

In the field of cancer virotherapy, many efforts are now focused on enhancing the immune response together with the direct lysis of tumor cells or inducement of apoptosis. One of the strategies that has emerged in this regard is the modification of viral vectors to encode for tumor-associated antigens (TAAs). The combination of viruses encoding TAAs with other approaches like the adoptive transfer of T cells, or the expression of multiple TAAs to target multiple epitopes, could also considerably improve the therapy and avoid tumor recurrence. This chapter focuses primarily on the recent advancements of adenovirus, poxvirus and vesicular stomatitis virus (VSV)-based preclinical studies, and clinical trials in tumour virotherapy.

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