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Managing blood lipids 

Managing blood lipids
Chapter:
Managing blood lipids
DOI:
10.1093/med/9780199674039.003.0014
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date: 18 August 2019

Hypercholesterolaemia, particularly raised low-density lipoprotein cholesterol, relates to cardiovascular disease in a graded manner and the relationship is causal. There is unequivocal evidence that treatment of hyperlipidaemia reduces cardiovascular disease events. European Guidelines retain a targeted approach—the higher the risk, the more intense the therapeutic advice. Current American guidance is for high-dose statin therapy for all very high-risk subjects. High triglycerides and low high-density lipoprotein cholesterol signal increase risk but trials do not support target values. High triglycerides are associated with central obesity, hypertension, low high-density lipoprotein cholesterol, and raised blood sugar. They may respond to weight control and alcohol reduction. Statins may increase blood sugar levels but the benefit associated with low-density lipoprotein lowering outweighs the adverse effect of this.

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