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Functional and epilepsy neurosurgery 

Functional and epilepsy neurosurgery
Chapter:
Functional and epilepsy neurosurgery
Author(s):

EAC Pereira

, AL Green

, RD Johnson

, KJ Bulluss

, A Astradsson

, JA Hyam

, and TZ Aziz

DOI:
10.1093/med/9780199674022.003.0005
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date: 03 August 2021

The two subspecialty areas of functional and epilepsy neurosurgery have become closer over recent years due to the wider use of neuromodulation procedures to control epilepsy including vagal nerve stimulation (VNS) and, more recently, deep brain stimulation (DBS). The first epilepsy surgery study discussed is a trial evaluating the efficacy of surgery in temporal lobe epilepsy refractory to medical management. The second section considers the two largest double-blind randomized trials evaluating VNS for the treatment of epilepsy and the SANTE trial of DBS. The next sections of this chapter deal with functional neurosurgery by way of DBS and its indications. Studies evaluating DBS for Parkinson’s disease (PD) are considered. This chapter includes a study that evaluates subgenual cingulated white matter as a target for DBS in treatment-resistant depression. Finally, important studies in the development of molecular and cellular therapies for PD are reviewed.

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