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Enhancement of neuroplasticity by drug therapy 

Enhancement of neuroplasticity by drug therapy
Chapter:
Enhancement of neuroplasticity by drug therapy
Author(s):

Ulf Ziemann

DOI:
10.1093/med/9780199673711.003.0017_update_001

Update:

Consolidation of the chapter by citation of the relevant new literature published between August 2014 and November 2015.

Updated on 26 May 2016. The previous version of this content can be found here.
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date: 20 February 2020

This chapter reviews effects of CNS active drugs specifically on activity-dependent plasticity and learning. The rationale for choosing this focus is the existing evidence that CNS active drugs have an impact on rehabilitation success after stroke to a relevant extent only if coupled with task-specific practice. This chapter reviews pharmacological modulation of stimulation induced long-term potentiation (LTP) in animal and human studies because synaptic plasticity in the form of LTP is a basic mechanism of learning and memory processes. Next, the chapter reviews the evidence of CNS active drugs on learning in animal and human studies. In the third part, the impact of CNS active drugs on neurorehabilitation of stroke patients is surveyed and the translational cascade from basic research to clinical studies is described. Finally, limitations of the current studies, open questions and future directions are discussed. This chapter demonstrates significant impact of neuropharmacology on activity-dependent plasticity and learning.

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