Show Summary Details
Page of

Animal models of damage, repair, and plasticity in the spinal cord 

Animal models of damage, repair, and plasticity in the spinal cord
Animal models of damage, repair, and plasticity in the spinal cord

V. Reggie Edgerton

, Roland R. Roy

, Daniel C. Lu

, and Yury Gerasimenko


May 26, 2016: This chapter has been re-evaluated and remains up-to-date. No changes have been necessary.

Page of

PRINTED FROM OXFORD MEDICINE ONLINE ( © Oxford University Press, 2021. All Rights Reserved. Under the terms of the licence agreement, an individual user may print out a PDF of a single chapter of a title in Oxford Medicine Online for personal use (for details see Privacy Policy and Legal Notice).

date: 02 August 2021

Sensorimotor function can improve for years, even after a spinal cord injury (SCI). We also know that an effective intervention that can improve motor function is re-engagement of the spinal neural networks and that this regularity in re-engagement is fundamental to learning within the activated sensorimotor circuits. Several interventions have been developed allowing individuals with a SCI to re-engage sensorimotor circuits. These interventions enable spinal neural circuits to neuromodulatethe level of excitability closer to a near motor threshold state.This is because of the built-in level of automaticity within the spinal circuits that then is translated into motor commands specified by the sensory input. Another increasingly apparent feature of the spinal circuitry is the highly integrated nature of multiple physiological systems linked to load bearing sensory input. Thus it is clear that multiple physiological systems are highly responsive to activity-dependent interventions after a severe SCI and that this responsiveness can persist for years post-injury.

Access to the complete content on Oxford Medicine Online requires a subscription or purchase. Public users are able to search the site and view the abstracts for each book and chapter without a subscription.

Please subscribe or login to access full text content.

If you have purchased a print title that contains an access token, please see the token for information about how to register your code.

For questions on access or troubleshooting, please check our FAQs, and if you can't find the answer there, please contact us.