- Preface
- Abbreviations
- Contributors
- Amendments and Updates
- Chapter 1 The International Classification of Functioning, Disability, and Health
- Chapter 2 An interdisciplinary approach to neurological rehabilitation
- Chapter 3 The economic benefits of rehabilitation for neurological conditions
- Chapter 4 Predicting activities after stroke
- Chapter 5 Designing a clinical trial for neurorehabilitation
- Chapter 6 The influence of age on neurorehabilitation
- Chapter 7 The applicability of motor learning to neurorehabilitation
- Chapter 8 Spinal neuronal dysfunction after deprivation of supraspinal input
- Chapter 9 Secondary changes after damage of the central nervous system: significance of spastic muscle tone in rehabilitation
- Chapter 10 Autonomic nervous system dysfunction
- Chapter 11 Functional recovery in CNS disease: impact of animal models
- Chapter 12 Animal models of damage, repair, and plasticity in the brain
- Chapter 13 Animal models of damage, repair, and plasticity in the spinal cord
- Chapter 14 Stem cell application in neurorehabilitation
- Chapter 15 The role of neuroimaging in understanding the impact of neuroplasticity after CNS damage
- Chapter 16 Enhancement of neuroplasticity by cortical stimulation
- Chapter 17 Enhancement of neuroplasticity by drug therapy
- Chapter 18 Rehabilitation of gait and balance after CNS damage
- Chapter 19 Neurorehabilitation approaches for disorders of the peripheral nervous system
- Chapter 20 Treatment of arm and hand dysfunction after CNS damage
- Chapter 21 Acquired disorders of language and their treatment
- Chapter 22 Neuropsychological rehabilitation of higher cortical functions after brain damage
- Chapter 23 The clinical neurology of problems with oral feeding
- Chapter 24 Management of bladder, bowel, and sexual dysfunction
- Chapter 25 The assessment and treatment of pain syndromes in neurorehabilitation
- Chapter 26 The impact of fatigue on neurorehabilitation
- Chapter 27 Neuropalliative rehabilitation—managing neurological disability in the context of a deteriorating illness
- Chapter 28 Recognition and management of functional (non-organic) symptoms after CNS damage
- Chapter 29 Promises and challenges of neurorehabilitation technology
- Chapter 30 Application of orthoses and neurostimulation in neurorehabilitation
- Chapter 31 Technology to enhance arm and hand function
- Chapter 32 Technology to enhance locomotor function
- Chapter 33 Enhancing independent community access and participation: services, technologies, and policies
- Chapter 34 Virtual reality for neurorehabilitation
- Index
(p. 129) Animal models of damage, repair, and plasticity in the brain
- Chapter:
- (p. 129) Animal models of damage, repair, and plasticity in the brain
- Author(s):
Andreas Luft
- DOI:
- 10.1093/med/9780199673711.003.0012
May 26, 2016: This chapter has been re-evaluated and remains up-to-date. No changes have been necessary.
Recovery after a stroke is a multidimensional process depending on the individual deficit. Within each functional domain, spontaneous recovery occurs to a variable degree and can be improved by specific neurorehabilitative interventions. The knowledge about the neurophysiology of the processes that lead to recovery and render neurorehabilitative interventions effective is scarce. Such knowledge, however, would be necessary to find new treatments that can fully exploit the brain’s capacity for recovery. Animal models can be an experimental platform to investigate these mechanisms. But it has to be realized that they oversimplify the human condition. The complexity of motor, cognitive, social, emotional, and other factors contributing to recovery in humans cannot be modelled in animals. The opportunities and caveats of animal models are discussed.
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- Preface
- Abbreviations
- Contributors
- Amendments and Updates
- Chapter 1 The International Classification of Functioning, Disability, and Health
- Chapter 2 An interdisciplinary approach to neurological rehabilitation
- Chapter 3 The economic benefits of rehabilitation for neurological conditions
- Chapter 4 Predicting activities after stroke
- Chapter 5 Designing a clinical trial for neurorehabilitation
- Chapter 6 The influence of age on neurorehabilitation
- Chapter 7 The applicability of motor learning to neurorehabilitation
- Chapter 8 Spinal neuronal dysfunction after deprivation of supraspinal input
- Chapter 9 Secondary changes after damage of the central nervous system: significance of spastic muscle tone in rehabilitation
- Chapter 10 Autonomic nervous system dysfunction
- Chapter 11 Functional recovery in CNS disease: impact of animal models
- Chapter 12 Animal models of damage, repair, and plasticity in the brain
- Chapter 13 Animal models of damage, repair, and plasticity in the spinal cord
- Chapter 14 Stem cell application in neurorehabilitation
- Chapter 15 The role of neuroimaging in understanding the impact of neuroplasticity after CNS damage
- Chapter 16 Enhancement of neuroplasticity by cortical stimulation
- Chapter 17 Enhancement of neuroplasticity by drug therapy
- Chapter 18 Rehabilitation of gait and balance after CNS damage
- Chapter 19 Neurorehabilitation approaches for disorders of the peripheral nervous system
- Chapter 20 Treatment of arm and hand dysfunction after CNS damage
- Chapter 21 Acquired disorders of language and their treatment
- Chapter 22 Neuropsychological rehabilitation of higher cortical functions after brain damage
- Chapter 23 The clinical neurology of problems with oral feeding
- Chapter 24 Management of bladder, bowel, and sexual dysfunction
- Chapter 25 The assessment and treatment of pain syndromes in neurorehabilitation
- Chapter 26 The impact of fatigue on neurorehabilitation
- Chapter 27 Neuropalliative rehabilitation—managing neurological disability in the context of a deteriorating illness
- Chapter 28 Recognition and management of functional (non-organic) symptoms after CNS damage
- Chapter 29 Promises and challenges of neurorehabilitation technology
- Chapter 30 Application of orthoses and neurostimulation in neurorehabilitation
- Chapter 31 Technology to enhance arm and hand function
- Chapter 32 Technology to enhance locomotor function
- Chapter 33 Enhancing independent community access and participation: services, technologies, and policies
- Chapter 34 Virtual reality for neurorehabilitation
- Index