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Mechanism of action of TENS 

Mechanism of action of TENS
Chapter:
Mechanism of action of TENS
DOI:
10.1093/med/9780199673278.003.0009
Page of

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date: 30 March 2020

There has been an abundance of research using animal, healthy human, and patients on the mechanism of action of TENS. Activity in peripheral nerves generated during TENS will influence physiological actions at peripheral, spinal, and supraspinal sites of the nervous system. Some of these physiological actions are mediated by alterations in the concentrations of neurochemicals dependent on the electrical characteristics of TENS. The purpose of this chapter is to discuss research evidence that has contributed to our knowledge about the physiological and pharmacological actions of TENS, including the mechanism of action of conventional TENS and AL-TENS, peripheral mechanisms of TENS, central mechanisms of TENS, findings from inflammatory and neuropathic models of pain, and the neuropharmacology of TENS hypoalgesia and TENS tolerance.

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