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Genetics of breast and ovarian cancer 

Genetics of breast and ovarian cancer
Genetics of breast and ovarian cancer

Deborah Ruddy

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date: 24 September 2021

Breast cancer is a common disease – ovarian cancer is less common. Mutations in the BRCA1 and BRCA2 genes account for up to10% of all breast and ovarian cancer. Mutations in the BRCA1, BRCA2 and TP53 confer high risks of cancer and genetic testing is offered where there is a 10% or greater chance of a mutation being identified in an individual. Other intermediate penetrance genes and genes associated with syndromic diagnoses have been identified which contribute to hereditary breast and ovarian cancer.

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