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Managing hereditary gynaecological cancers 

Managing hereditary gynaecological cancers
Chapter:
Managing hereditary gynaecological cancers
Author(s):

Charlotte Moss

, Emma Crosbie

, and Ana Montes

DOI:
10.1093/med/9780199672844.003.0030
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date: 20 August 2019

As oncologists treating gynaecological malignancies we frequently encounter patients with proven or suspected hereditary predisposition to cancer development. Some of these cancers have a different behaviour to sporadic cancers in their epidemiology and prognosis. Knowledge of these patterns of disease enables us to monitor and counsel patients adequately. More importantly, discovery of the faulty pathways associated with hereditary cancers can be exploited therapeutically and there is an important role for new agents alone or in combination with conventional cytotoxic chemotherapy. This chapter reviews the current surgical and medical management of patients with proven hereditary gynaecological malignancies, focusing on BRCA-related ovarian cancer and Lynch Syndrome-related ovarian and endometrial cancer.

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