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Managing hereditary colorectal and gastric cancer 

Managing hereditary colorectal and gastric cancer
Managing hereditary colorectal and gastric cancer

Kiruthikah Thillai

, Claire Coughlan

, Mahmoud Ali Zohree Ali

, and Paul Ross

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date: 12 July 2020

Cancers of the gastro-intestinal tract remain a leading cause of cancer-associated mortality. Although the majority of cases are sporadic, there are certain familial syndromes that harbour a genetic predisposition to developing malignancy. Whilst the preponderance of familial cases are treated with the same anti-cancer treatment as sporadic cases, there is a small cohort that benefit from different management. There is now substantial evidence to suggest that patients with colorectal tumours demonstrating micro-satellite instability have differing responses to certain chemotherapeutic agents compared to those with tumours that are micro-satellite stable. Early identification of genetic syndromes is important in managing new cases of cancer, not just for its differing surveillance programmes but also for the variations in anti-cancer management that may be needed.

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