Show Summary Details
Page of

Managing hereditary colorectal and gastric cancer 

Managing hereditary colorectal and gastric cancer
Chapter:
Managing hereditary colorectal and gastric cancer
Author(s):

Kiruthikah Thillai

, Claire Coughlan

, Mahmoud Ali Zohree Ali

, and Paul Ross

DOI:
10.1093/med/9780199672844.003.0029
Page of

PRINTED FROM OXFORD MEDICINE ONLINE (www.oxfordmedicine.com). © Oxford University Press, 2016. All Rights Reserved. Under the terms of the licence agreement, an individual user may print out a PDF of a single chapter of a title in Oxford Medicine Online for personal use (for details see Privacy Policy and Legal Notice).

date: 20 August 2019

Cancers of the gastro-intestinal tract remain a leading cause of cancer-associated mortality. Although the majority of cases are sporadic, there are certain familial syndromes that harbour a genetic predisposition to developing malignancy. Whilst the preponderance of familial cases are treated with the same anti-cancer treatment as sporadic cases, there is a small cohort that benefit from different management. There is now substantial evidence to suggest that patients with colorectal tumours demonstrating micro-satellite instability have differing responses to certain chemotherapeutic agents compared to those with tumours that are micro-satellite stable. Early identification of genetic syndromes is important in managing new cases of cancer, not just for its differing surveillance programmes but also for the variations in anti-cancer management that may be needed.

Access to the complete content on Oxford Medicine Online requires a subscription or purchase. Public users are able to search the site and view the abstracts for each book and chapter without a subscription.

Please subscribe or login to access full text content.

If you have purchased a print title that contains an access token, please see the token for information about how to register your code.

For questions on access or troubleshooting, please check our FAQs, and if you can't find the answer there, please contact us.