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Managing hereditary breast cancer 

Managing hereditary breast cancer
Managing hereditary breast cancer

Jennifer Glendenning

, Ashutosh Kothari

, Amanda Shewbridge

, and Andrew Tutt

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date: 14 July 2020

Following a diagnosis of primary breast cancer the accurate and timely identification of those who may have an underlying genetic predisposition, most commonly due to BRCA1 or BRCA2 mutation carrier status, is very important. Confirmation of mutation carrier status may influence management decisions across the breadth of the multidisciplinary team, particularly with regard to therapy sequencing and choice and extent of surgery. This chapter reviews the impact of suspected genetic breast cancer on the therapeutic approach for the index breast, risk-reducing surgery options including breast reconstruction and the additional psychosocial support needs of affected individuals through their diagnostic and treatment pathway.

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