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Early detection of hereditary colorectal and gastric cancer 

Early detection of hereditary colorectal and gastric cancer
Early detection of hereditary colorectal and gastric cancer

Abdulkani Yusuf

and Kevin John Monahan

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date: 12 July 2020

There is considerable evidence for colorectal cancer risk reduction by screening in both average-risk and high-risk populations. The average-risk population in the UK is currently invited to take part in the NHS Bowel Cancer Screening Programme. At present this consists of 2-yearly faecal occult blood stool testing followed by colonoscopy where the stool test is abnormal. Additional flexible sigmoidoscopy will soon also be offered to 55-year-olds. High-risk individuals are recommended to undergo colonoscopic and upper gastrointestinal surveillance depending on their level of risk. Individuals with highly penetrant conditions such as Lynch syndrome and familial adenomatous polyposis should be referred to clinical genetics centres, and moderate-risk patients with a family history of cancer can be referred to secondary care for assessment. Gastric cancer screening is not currently offered to the average-risk population in the UK, but is available for certain high-risk groups with highly penetrant genetic susceptibility.

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