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Risk assessment in colorectal, gastric and related gynaecological cancers 

Risk assessment in colorectal, gastric and related gynaecological cancers
Risk assessment in colorectal, gastric and related gynaecological cancers

Sarah Rose

and Vicki Kiesel

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date: 12 July 2020

The majority of colorectal cancer is sporadic; however, 3–5% is due to an inherited genetic predisposition with a further 10–15% estimated to be familial (due to intermediate- or low-penetrance variants and/or lifestyle factors). Accurate risk assessment of families enables targeted screening thereby decreasing the morbidity and mortality caused by colorectal, gastric and associated cancers. Within high- and moderate-risk family histories there are several significant clues, including histopathology, which can enable clinicians to correctly categorise these families by risk. It is important to ensure that the correct information is obtained to allow an accurate risk assessment. Appropriate management strategies can then be explored. The risk assessment and recommended screening strategies can subsequently be explained to both the patient and other clinicians. Referrals to genetics can be made for appropriate families.

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