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Genetics of prostate cancer 

Genetics of prostate cancer
Chapter:
Genetics of prostate cancer
Author(s):

Audrey Ardern-Jones

, Elizabeth Bancroft

, and Rosalind Eeles

DOI:
10.1093/med/9780199672844.003.0010
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date: 20 August 2019

Prostate cancer is the most common cancer in men in the Western world. There is evidence that there is a genetic component to prostate cancer development from familial and epidemiological studies. Mutations in BRCA1 and BRCA2 and HOXB13 have been implicated in the development of prostate cancer, but only account for a very small percentage of the disease burden. To date, genome-wide association studies have identified 77 genetic variants associated with prostate cancer risk. They have a lower penetrance but are common and can cause a substantially increased risk in a man with several variants. Knowledge about these variants will enable screening and therapeutic agents to be targeted at those men who will benefit most.

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