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Hormone resistance syndromes 

Hormone resistance syndromes
Hormone resistance syndromes

Helen E. Turner

, Richard Eastell

, and Ashley Grossman

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date: 15 April 2021

This chapter discusses clinical features, epidemiology, and management/treatment strategies for resistance to hormones such as thyroid receptor alpha and beta resistance to thyroid hormone (TR-alpha RTH and TR-beta RTH, respectively). It also discusses androgen insensitivity, as in resistance to testosterone and dihydrotestosterone, which can result in complete, partial, and mild forms of androgen insensitivity. It describes Chrousos syndrome, which is a type of glucocorticoid resistance, and its clinical manifestations, molecular mechanisms, and clinical evaluation. The chapter also describes resistance to adrenocorticotrophin hormone, and the potentially resulting familial glucocorticoid deficiency (FGD) and triple A syndrome. It also discusses aldosterone resistance, describing potential manifestations such as generalized pseudohypoaldosteronism type 1 (PHA1) and renal PHA1.

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