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Antimanic drugs 

Antimanic drugs
Antimanic drugs

Basant K. Puri

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date: 08 December 2021

The use of antimanic drugs

Treatment strategies for bipolar I disorder

Lithium salts


Valproic acid

Second-generation antipsychotics


The antimanic drugs considered in this chapter are lithium salts, carbamazepine, and semisodium valproate (containing valproic acid). Lithium carbonate and lithium citrate are particularly useful in the prophylaxis of bipolar mood disorder, as well as having a role in the treatment of mania itself. The antiepileptic drug carbamazepine may be used as an alternative to lithium salts in the prophylaxis of bipolar mood disorder in patients who do not respond to lithium salts, particularly in those who are rapid cyclers suffering at least 4 relapses (mania or depression) per year. Valproic acid (semisodium valproate) is an effective treatment for mania in many cases of bipolar disorder....

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